One of the defining features of chemical biology is the design and application of small-molecule ligands as chemical probes to study biology. Chemical probes that are designed to interact with a specific macromolecule or small-biomolecule – with high affinity and selectivity – can facilitate the study of phenotypes associated with the macromolecule or small-biomolecule and its function. The organizers of the conference are focused on designing and applying chemical probes to explore the structure and function of biomolecules. Their work includes developing and utilizing small molecules for sample design and preparation in X-ray and neutron scattering experiments.
PROGRAMME (detailed agenda to follow)
3 September 2024
9.00 Introduction & Welcome
9.15 “Developing chemical tools to study Histone Deacetylase enzymes in corepressor complexes” – Dr James Hodgkinson, LISCB
9.45 “Using aldehydes to treat disease” – Dr Richard Hopkinson, LISCB
10.15 Morning coffee/fika
10.45 “Reactive Sulfur Species: biology’s dark matter comes to light” – Dr Christopher Switzer, LISCB
11.15 “Structure-based design and synthesis of macrocyclic ligands as novel galectin-3 inhibitors” – Fredrik Sjövall, Lund University
11.35 Common discussion on potential collaboration opportunities, joint grant applications, students
12:00 Lunch @ LINXS
13:00 Transfer to ESS
13:30 Site visit (safety induction, PPE, walk to labs, experimental halls)
15:45 Afternoon coffee/tea @ ESS
16:15 Leave ESS
18:00 Dinner at LINXS
4 September 2024
9:00 Prof. Steve Bull, LISCB (remote presentation)
9:30 “Understanding the RAS signalling under physiological conditions” – Dr. Kayoko Tanaka, LISCB
10:00 “Developing small molecule inhibitors to overcome apoptosis resistance” –Dr Joanna Fox, LISCB
10:30 Morning coffee/fika
11:00 Common discussion on potential collaboration opportunities, joint grant applications, students
11:45 Close-out, next steps, planning for next meeting/event
12:00 Lunch @ LINXS and departure