Pilot Projects

Approved Projects

Here you can find descriptions of the HALRIC pilot projects. More projects will be added as they are approved.

A list of the Research Infrastructures that have been used in the approved HALRIC pilot projects can be found here for inspiration.

 

Targeting aquaporins as breast cancer therapeutics

EMBION and/or MAXIV

Lund University (LU) |Aarhus University (AU) |Apoglyx AB (Industry partner)

Implementation of a pioneering hardware agnostic smart microscopy solution at LBIC and CFIM

Lund University Bioimaging Centre (LBIC) |Core Facility for Integrated Microscopy (CFIM) at UCPH

Lund University (LU) |University of Copenhagen (UCPH) |Cytely AB (Industry partner)

Inhaled biopharmaceuticals: understanding the interactions between drug carrier and the biological barrier in the lung

MAX IV (CoSAXS)

Malmö University (MaU) |University of Copenhagen (UCPH) |Truly Labs AB (Industry Partner)

Development and validation of multiplex FISH as a tool for spatially mapping the transcriptome

LBIC, Lund University |DaMBIC, University of Southern Denmark

Lund University (LU) |Skåne University Hospital (SUS) |University of Southern Denmark (SDU)

Improving Dental Cellular Tissue Imaging through Multi-Methodical Micro-CT Imaging

microCT at University of Oslo |SOLEIL Synchrotron |Elettra Sincrotrone |MAX IV

University of Oslo |Malmö University |MAX IV

Understanding molecular basis for DNA recognition by bacterial Cro-domain proteins

Deutsche Elektronen-Synchroton (DESY) |Biophysics and biochemical core facility at Aarhus University |Sample preparation and Characterization at EMBL Hamburg

Aarhus University (AU) |DESY

Exploring the anti-inflammatory potential of reconstituted high-density lipoprotein (rHDL) particles

CryoEM for Life Sciences |SAXS at Aarhus University

Aarhus University |Lund University |Malmö University

Investigating alpha synuclein liquid-liquid phase separation by combining timeresolved X-ray scattering and computer simulations

MAX IV |SCIENCE HPC Center at UCPH |Protein Production Facility at UCPH

University of Copenhagen (UCPH) |MAXIV

Hepatocellular carcinoma: 3D microscopy scanning to characterize microvascular invasion

3DIM/DANFIX at DTU |MAX IV |BRIC at UCPH |Department of Experimental Medical Science at LU |Correlative Image Processing and Analysis Image (CIPA) |InfraVis

University of Copenhagen (UCPH) |Lund University (LU) |Rigshospitalet (RH) |Denmark Technical University (DTU)

Investigating lung tissue strain in lung injury and ventilator-induced stress

DANFIX |LBIC |InfraVis

Lund University |Technical University of Denmark

Fast and efficient scattering prediction in protein samples

ESS datacenter |LUNARC |Faunus

Lund University (LU) |European Spallation Source (ESS)

Expandable full-project platform for high-throughput drug development and related experiments

DESY

Denmark Technical University (DTU) |DESY |Sai Life Sciences (industry partner)

Uptake and plant growth enhancement for nano-enabled agriculture

National Center for Nanofabrication and Nanocharacterisation (DTU) |BioMS (LU) |MAX IV

Aarhus University (AU) |Lund University (LU) |Technical University of Denmark (DTU)

Unraveling molecular players responsible for genomic stability

MAX IV |LU - Division of Food and Pharma

University of Oslo |Lund University

Towards time-resolved studies of the Lytic Polysaccharide Monooxygenase reaction

MAX IV

University of Copenhagen |Lund University

Combining SAXS and Fluorescence Spectroscopy to uncover membrane dynamics towards antimicrobial peptide-based antibiotics

MAX IV |RECX |ESRF

University in Oslo |Lund University

Understanding how different particle populations in lipid nanoparticles work for better mRNA delivery

MAX IV

University of Copenhagen |Lund University

Investigating the mechanism of action of parthenolide: A foundation for anti-mitotic drug development

PX-Oslo at UiO |Hydrogen-deuterium exchange mass spectrometry HDX-MS at UiO |Isothermal titration calorimetry (ITC) at UCPH |Pulsed EPR facility at UCPH |NMR at UCPH |Super computers at UCPH |MAX IV

University of Oslo (UiO) |University of Copenhagen (UCPH)

Structural studies of zonulin and its potential role in celiac disease and as biomarker in IBD

DESY |EMBION

Aarhus University |University Medical Center Hamburg-Eppendorf (UKE)

Exploring therapeutic and diagnostic potentials of bispecific antibodies towards coronaviruses from atomic level to clinical practice

Lund University Virus Centre (LUVC) |Lund Protein Production Platform (LP3) |MAX IV |CIPA |SciLifeLab

Lund University (LU) |Skåne University Hospital (SUS) |Aarhus University (AU)

Limiting the cell toxicity of antimicrobial peptides through NMR spectroscopy

cOpenNMR

University of Copenhagen |University of Oslo

Developing a drug delivery system for the antifungal agent Amphotericin B

European Synchroton Radiation Facility (BioSAXS) |PSI (SANS)

University of Oslo |University of Copenhagen

Engineering biocompatible microcapsules for targeted enzyme delivery to enhance anticancer treatments

MAX IV |EMBION

Lund University |Aarhus University |Malmö University |University of Copenhagen

Facilitating Drug Design with Fragment-based Active Site Exploration (FASE)

FragMAX, BioMAX – MAX IV Laboratory

Aarhus University

Data management of proof-of-concept study to understand intrinsically disordered proteins

European XFEL |MAX IV |LUNARC |NAISS

Lund University

Unravelling the Internal Structure and Molecular Exchange Kinetics of Antibiotic Polymeric Nanoparticles

RECX |ILL |PSI |SAXS at Aarhus University

University of Oslo |Aarhus University

Solution scattering techniques towards therapeutic interventions of CIC-1-associated diseases

MAX IV |DESY |ILL/ESS |Cryo-EM at SciLifeLab and EMBION

University of Copenhagen |University of Hamburg |Lund University |NMD Pharma (Industry Partner)

Exploring X-ray tomographic microscopy in severe autoimmune asthma, to identify lung structures and assess treatment

DANFIX |XRTM at DTU Physics and LU

Bispebjerg Hospital (BH) |Lund University (LU) |Technical University of Denmark (DTU)

Investigating Amyloid Fibril‐Protein Interactions and Their Impact on Neuroinflammation

BioMS |Bispebjerg BrainBank |Zebrafish Facility at AU

DTU |Aarhus University (AU) |Bispebjerg Hospital (BH) |Lund University (LU)

Probing Pea Protein Digestion Dynamics: A Multiscale Exploration addressing allergenicity potentials

EMBL Hamburg (DESY) |MAX IV Laboratory

Malmö University |Lund University

Targeting aquaporins as breast cancer therapeutics

EMBION |BMC Lund

Aarhus University |Lund University |Apoglyx AB (Industry Partner)

Feasibility of using Micro–CT to optimize surgical precision in oral cancer

MAX IV Laboratory |DTU Micro-CT |DTU Compute

Rigshospitalet |Technical University of Denmark (DTU)

Proof of concept study to understand intrinsically disordered proteins by combining scattering and imaging techniques at EuXFEL

European XFEL |MAX IV

Lund University

Unraveling Molecular Structures for Anti-Amyloid Drug Development with Synchrotron-based Spectroscopy

Medical Microspectrocopy Lab |LBIC |CIPA |Astrid2 |MAX IV Laboratory |SAXS at Aarhus University

Lund University |Aarhus University |Strominnate Therapeutics (Industry Partner)

Advancing cellular infection models in the search for new antibiotics

Center for Structural Systems Biology (CSSB) |NMR Center at DTU

Technical University of Denmark (DTU) |University of Hamburg (UHH) |JD Coils (Industry Partner)

HALRIC Pilot Project PP03

Decipher protease zymogen activation to enable stroke therapy

Danish National cryo-EM facility (EMBION)

Aarhus University |University of Oslo

Spatial proteomic profiling of cardiovascular tissues

BioMS |Core Facility for Integrated Microsopy (CFIM) |Protein Oxidation Laboratory |Swedish biobank of human carotid artery atherosclerotic plaques (CPIP)

Lund University |Skåne University Hospital |University of Copenhagen